No. N-Gone works well on any N-Gone based Mesh, including Meshes made with a boolean Workflow in Blender or other 3d Software.
also it has Tools to help optimize ultra high poly sculpts and photo scans.

N-Gone Pro, is at its core a labor saving device, it condenses many repetitive tasks when preparing an export mesh for texturing software.
It helps handle Naming Conventions, For Low poly it Decimates a mesh while preserving its normal's for a cleaner Mesh, and for high poly it reduces the chance of errors in the Texturing software or game engine, by simultaneously Preserving the normal's and ensuring the mesh is triangulated.
It also has Tools for created U.V'ss on the fly for multiple meshes at once.